Assessment of Neuropharmacological Profile of Ethanolic Extract of Lawsonia Inermis Flowers

Authors

  • Syeda Nishat Fathima Department of Pharmacology, Jayamukhi College of Pharmacy, Narsampet, Telangana; India
  • G Hemalatha Department of Pharmacology, Jayamukhi College of Pharmacy, Narsampet, Telangana; India
  • T Smitha Department of Pharmacology, Jayamukhi College of Pharmacy, Narsampet, Telangana; India
  • M Rama Department of Pharmacology, Jayamukhi College of Pharmacy, Narsampet, Telangana; India

Abstract

On preliminary basis neuropharmacological profile of ethanolic extract of flowers of Lawsonia inermis was carried out. For assessing the activity of flowers on central nervous system locomotor activity using actophotometer, muscle relaxant activity using rotarod apparatus, pentobarbital-induced hypnosis and anticonvulsant activity by maximal electroshock test was performed.  Ethanolic extract of flowers of Lawsonia inermis decreased the motor activity by 48.63 % and showed 49.03% noteworthy muscle relaxation along with 127.73% potentiation of pentobarbital-induced sleeping time and 66.67% decreased the duration of tonic hind leg extension of seizures activity.  The results conclude that the extract of flowers of Lawsonia inermis has significant central nervous system depressant activity. Further investigations are, however, necessary to explore mechanism(s) of action involved in these pharmacological activities.

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Published

2020-12-02