Mapana Journal of Sciences

A systematic study towards the synthesis, isolation and recrystallization of Atovaquone, an antimalarial drug: a sustainable synthetic pathway

Sanjay, Shashiprabha, Shridhara, Nagarajan, Ranganathan — Sat, 01 Jan 2022 00:00:00 +0000

In the present work, studies were conducted towards the synthesis of Atovaquone 5 with systematic reaction and recrystallization condition optimization to isolate 5 in high yield with better purity. Synthesis of 5 was done by the hydrolysis of 2-[trans-4-(4-chlorophenyl) cyclohexyl]-3-chloro-1,4-naphthoquinone 4, which was isolated by the decarboxylative condensation of trans-4-(4-chlorophenyl) cyclohexane carboxylic acid 3 with naphthoquinone moiety. After the hydrolysis of 4, isolation of crude 5 was done by the use of acetic acid instead of dilute hydrochloric acid, product 5 was isolated in good purity with very less polar impurities. The use of a large volume of solvent becomes a bottleneck for the commercial synthesis of 5. Our efforts towards optimization of hydrolysis reaction and recrystallization of 5 with the use of small volume of solvent combination had made the process to be more cost effective and commercially viable for large scale manufacturing.

Removal of Iron and Chromium from Effluent Water of Steel Plant Using Syzygium Cumini Seed

Satheesh Dhurairaj — Tue, 17 May 2022 00:00:00 +0000

In the current scenario health of people has been greatly incriminated due to heavy metal defilementation. Modernization and industrial enterprise are the major cause for the incorporation of heavy metals in the environment. The most precarious heavy metals which are found to impinge water bodies are chromium, mercury, lead, cadmium, iron etc. Most of the treatment techniques are found to be risk due to the production of secondary pollutant. Such problem can be rectified by the use of natural adsorbents which will reduce the secondary pollutant to large extent. The most efficacious and economic process for the removal of toxic heavy metal is biosorption. Present investigation aims to analyse the effluent water generated from steel plant and remove heavy metals like iron and chromium from it using Syzigium Cumini seed powder as adsorbent.

Open Support Strong Efficient Domination Number of Some Standard Graphs Under Addition and Multiplication

Murugan K, Meena — Tue, 17 May 2022 00:00:00 +0000

Let G = (V, E) be a graph with p points and q nodes. Let S be a - set of G. Let v S. An open support strong efficient domination number of v under addition is defined by and it is denoted by supp An open support strong efficient domination number of G under addition is defined by and it is denoted by supp . An open support strong efficient domination number of v under multiplication is defined by and it is denoted by supp An open support strong efficient domination number of G under multiplication is defined by and it is denoted by supp In this paper, open support strong efficient domination number of some standard graphs is studied.and the results are presented

Quantum Game Theoretic Analysis of Kabaddi

Swati Singh — Tue, 17 May 2022 00:00:00 +0000

The paper attempts to quantize Kabaddi using game-theoretic analysis. The authors' design payoff matrices using classical game theory. There are multiple pure and mixed strategy Nash equilibria for the matrices. The dilemma resolves using the quantization of Kabaddi, and we obtain a unique solution to the payoff matrix. It also shows how a player can modify another player's winning by choosing its angles.

A Recommender System: Challenges, Issues & Extensions

Dheeraj Kumar Sahni — Tue, 17 May 2022 00:00:00 +0000

Recommendations are long chains followed from traditional life to today’s life. In everyday life, the chain of recommendation augments the social process via some physical media and digital applications. The issues and challenges of recommendation are still in the infancy due to the growth of technology. This article identifies the uncovered areas of concern and links them to novel solutions. We also provide an extensive literature with different dimension for the newbie to work with the subject. We observed the study with different taxonomy provided by the prevalent researcher of the recommender system. This article gives the remedial solution of the recommendation problems