Application of FBRM Technology in the crystallization process (A perspective)

Authors

  • Vandana R Department of Chemistry, CHRIST (Deemed to be University)
  • Pragya Anand Department of Chemistry, CHRIST (Deemed to be University)

Keywords:

Solvent selection, Solubility, Seeding, PAT techniques

Abstract

Crystallisation is a two-step process, Step 1 being Nucleation (commencement of the new phase) & Step 2 being subsequent growth of nuclei to crystals. The pre-requisite for crystallisation to occur is the formation of a super-saturated solution, which is in a non-equilibrium state. From this point forward, the process is all about moving toward an equilibrium point, to achieve crystal formation.

Author Biographies

Vandana R, Department of Chemistry, CHRIST (Deemed to be University)

CHRIST (Deemed to be University), Hosur Road, Bengaluru 560029, India

Pragya Anand, Department of Chemistry, CHRIST (Deemed to be University)

CHRIST (Deemed to be University), Hosur Road, Bengaluru 560029, India

 

References

Tom Leyssens, Carine Baudry, Maria Luisa Escudero Hernandez‡ Org. Process Res. Dev. 2011, 15, 2, 413-426

Vijay Kumar, Michael K. Taylor, Amit Mehrotra, and William C. Stagner

AAPS PharmSciTech. 2013, 14, 523–530.

Min Su, Lin Wang, Hua Sun, Jingkang Wang Frontiers of Chemical Engineering in China 2009, 3, 282–288.

Panel K.PandalaneniJ.K.Amamcharla 2016, 99, 7, 5244-5253

Additional Files

Published

2021-08-28

Issue

Vol. 19 No. 2 (2020): Mapana Journal of Sciences

Section

Perspective

License

Copyright (c) 2020 Mapana Journal of Sciences

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