Synthesis of a New Series of Quinolinoxymethylcoumarins as Potent Anticancer Agents
DOI:
https://doi.org/10.12723/mjs.25.5Keywords:
4-Bromomethylcoumarins, Coumarins, Quinoline, Cytotoxic activity.Abstract
4-Bromomethylcoumarins (1a-f) were reacted with 8-hydroxyquinoline to yield quinolinoxymethylcoumarins (2a-f). The structure of all the synthesized compounds were confirmed by spectral studies and screened for their anticancer activities against Dalton’s Ascitic lymphoma (DAL) and Ehrlich Ascites Carcinoma (EAC) cell lines. Out of these, compound (2b) (R = 6-OMe) was found to be the most potent cytotoxic compound against DAL and EAC cell lines.
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