In Vitro Cell Culture Drug Resistance Testing

Abstract

Drug development and screening programme for the identification Of a novel concer
chemotherapeutic agent involves extensive preclin iCal evaluation of vast n umber
Of chemicals for detection 0' their antineoplastic activity. The safety Of drugs
the screening strategies (Freshney, 1992).
The development Of drug resistance is a rnaior obstacle to effectiveness Of
chemoåterapeutic treatment 0/ human tumors with cytotoxic agents. Drug resistance
is described as a multifactor phenomenon, involving the expression Of defense '
factors