Research Articles
Published 2017-04-01
Keywords
- Anti-cancer activity,
- ZnO nanoparticles,
- Cancer cellines,
- cytotoxicity
Copyright (c) 2017
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Abstract
Several methods are used to counter the deadly disease cancer. Zinc oxide nanoparticles (ZnO NPs) is one of the metal oxide nanoparticles which had been used in anti-cancer activities due to its large bandwidth and high exciting binding energy and it has potential applications like antibacterial, antifungal, anti-diabetic, anti-inflammatory, wound healing, antioxidant, optic properties and also which holds promise to treat cancer effectively. Studies have shown that Zinc metal oxide nano particles induce cytotoxicity in cancer cells. The mechanism for antitumor could work through apoptosis or the generation of reactive oxygen species or and necrosis, among other possibilities. This review is on some of the most significant antitumor results obtained with zinc oxide nanoparticles depending on their size, surface morphology, methods of preparation and also cytotoxicity result.
References
[1] Vinardell MP, Mitjans M. Antitumor activities of metal oxide nanoparticles. Nanomaterials. 2015 Jun 9;5(2):1004-21.
[2] Wang R, Billone PS, Mullett WM. Nanomedicine in action: an overview of cancer nanomedicine on the market and in clinical trials. Journal of Nanomaterials. 2013 Jan 1;2013:1.
[3] McNeil SE. Nanoparticle therapeutics: a personal perspective. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 2009 May 1;1(3):264-71.
[4] Vizirianakis IS. Nanomedicine and personalized medicine toward the application of pharmacotyping in clinical practice to improve drug-delivery outcomes. Nanomedicine: Nanotechnology, Biology and Medicine. 2011 Feb 28;7(1):11-7.
[5] Shen C, James SA, de Jonge MD, Turney TW, Wright PF, Feltis BN. Relating cytotoxicity, zinc ions, and reactive oxygen in ZnO nanoparticle–exposed human immune cells. toxicological sciences. 2013 Aug 31;136(1):120-30.
[6] Kołodziejczak-Radzimska A, Jesionowski T. Zinc oxide—from synthesis to application: a review. Materials. 2014 Apr 9;7(4):2833-81.
[7] Nel A, Xia T, Mädler L, Li N. Toxic potential of materials at the nanolevel. science. 2006 Feb 3;311(5761):622-7.
[8] Vaseem M, Umar A, Hahn YB. ZnO nanoparticles: growth, properties, and applications. Metal oxide nanostructures and their applications. 2010;5:1-36.
[9] Zhang H, Chen B, Jiang H, Wang C, Wang H, Wang X. A strategy for ZnO nanorod mediated multi-mode cancer treatment. Biomaterials. 2011 Mar 31;32(7):1906-14.
[10] Hanley C, Layne J, Punnoose A, Reddy KM, Coombs I, Coombs A, Feris K, Wingett D. Preferential killing of cancer cells and activated human T cells using ZnO nanoparticles. Nanotechnology. 2008 Jun 10;19(29):295103.
[11] Ostrovsky S, Kazimirsky G, Gedanken A, Brodie C. Selective cytotoxic effect of ZnO nanoparticles on glioma cells. Nano Research. 2009 Nov 1;2(11):882-90.
[12]Premanathan M, Karthikeyan K, Jeyasubramanian K, Manivannan G. Selective toxicity of ZnO nanoparticles toward Gram-positive bacteria and cancer cells by apoptosis through lipid peroxidation. Nanomedicine: Nanotechnology, Biology and Medicine. 2011 Apr 30;7(2):184-92.
[13] Emima Jeronsia. J, Allwin Joseph, L. and Jerome Das, S. INVESTIGATIONS ON ANTICANCER AND ANTIBACTERIAL ACTIVITIES OF ZINC OXIDE NANOPARTICLES International Journal of Development Research Vol. 5, Issue, 10, pp. 5707-5711, October, 2015[
[14] Wahab R, Siddiqui MA, Saquib Q, Dwivedi S, Ahmad J, Musarrat J, Al-Khedhairy AA, Shin HS. ZnO nanoparticles induced oxidative stress and apoptosis in HepG2 and MCF-7 cancer cells and their antibacterial activity. Colloids and Surfaces B: Biointerfaces. 2014 May 1;117:267-76.
[15] Wahab R, Dwivedi S, Umar A, Singh S, Hwang IH, Shin HS, Musarrat J, Al-Khedhairy AA, Kim YS. ZnO nanoparticles induce oxidative stress in Cloudman S91 melanoma cancer cells. Journal of biomedical nanotechnology. 2013 Mar 1;9(3):441-9.
[16] Hackenberg S, Scherzed A, Kessler M, Froelich K, Ginzkey C, Koehler C, Burghartz M, Hagen R, Kleinsasser N. Zinc oxide nanoparticles induce photocatalytic cell death in human head and neck squamous cell carcinoma cell lines in vitro. International journal of oncology. 2010 Dec 1;37(6):1583-90.
[17] Fang RH, Hu CM, Luk BT, Gao W, Copp JA, Tai Y, O’Connor DE, Zhang L. Cancer cell membrane-coated nanoparticles for anticancer vaccination and drug delivery. Nano letters. 2014 Mar 28;14(4):2181-8.
[18] Bae MY, Cho NH, Seong SY. Protective anti‐tumour immune responses by murine dendritic cells pulsed with recombinant Tat‐carcinoembryonic antigen derived from Escherichia coli. Clinical & Experimental Immunology. 2009 Jul 1;157(1):128-38.
[19] Cho NH, Cheong TC, Min JH, Wu JH, Lee SJ, Kim D, Yang JS, Kim S, Kim YK, Seong SY. A multifunctional core-shell nanoparticle for dendritic cell-based cancer immunotherapy. Nature nanotechnology. 2011 Oct 1;6(10):675-82.
[20] Yun JW, Yoon JH, Kang BC, Cho NH, Seok SH, Min SK, Min JH, Che JH, Kim YK. The toxicity and distribution of iron oxide–zinc oxide core‐shell nanoparticles in C57BL/6 mice after repeated subcutaneous administration. Journal of Applied Toxicology. 2015 Jun 1;35(6):593-602.
[21] Selvakumari D, Deepa R, Mahalakshmi V, Subhashini P, Lakshminarayan N. Anti cancer activity of ZnO nanoparticles on MCF7 (breast cancer cell) and A549 (lung cancer cell). Asian Research Publishing Network Journal of Engineering and Applied Sciences. 2015;10:5418-21.
[22] Bezerra DP, Pessoa C, Moraes MO, Silveira ER, Lima MA, Martins Elmiro FJ, Costa-Lotufo LV. Antiproliferative effects of two amides, piperine and piplartine, from Piper species. Zeitschrift für Naturforschung C. 2005 Aug 1;60(7-8):539-43.
[23] Sriwiriyajan S, Ninpesh T, Sukpondma Y, Nasomyon T, Graidist P. Cytotoxicity screening of plants of genus piper in breast cancer cell lines. Tropical Journal of Pharmaceutical Research. 2014;13(6):921-8.
[24] Roy UB, Vijayalaxmi KK. Evaluation of in vitro antitumor property of ethanolic extract of Piper Nigrum seeds. International Journal of Biotechnology and Allied Fields. 2013;1(9):419-37.
[25] Prashant A, Rangaswamy C, Yadav AK, Reddy V, Sowmya MN, Madhunapantula S. In vitro anticancer activity of ethanolic extracts of Piper nigrum against colorectal carcinoma cell lines. International Journal of Applied and Basic Medical Research. 2017 Jan;7(1):67.
[2] Wang R, Billone PS, Mullett WM. Nanomedicine in action: an overview of cancer nanomedicine on the market and in clinical trials. Journal of Nanomaterials. 2013 Jan 1;2013:1.
[3] McNeil SE. Nanoparticle therapeutics: a personal perspective. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology. 2009 May 1;1(3):264-71.
[4] Vizirianakis IS. Nanomedicine and personalized medicine toward the application of pharmacotyping in clinical practice to improve drug-delivery outcomes. Nanomedicine: Nanotechnology, Biology and Medicine. 2011 Feb 28;7(1):11-7.
[5] Shen C, James SA, de Jonge MD, Turney TW, Wright PF, Feltis BN. Relating cytotoxicity, zinc ions, and reactive oxygen in ZnO nanoparticle–exposed human immune cells. toxicological sciences. 2013 Aug 31;136(1):120-30.
[6] Kołodziejczak-Radzimska A, Jesionowski T. Zinc oxide—from synthesis to application: a review. Materials. 2014 Apr 9;7(4):2833-81.
[7] Nel A, Xia T, Mädler L, Li N. Toxic potential of materials at the nanolevel. science. 2006 Feb 3;311(5761):622-7.
[8] Vaseem M, Umar A, Hahn YB. ZnO nanoparticles: growth, properties, and applications. Metal oxide nanostructures and their applications. 2010;5:1-36.
[9] Zhang H, Chen B, Jiang H, Wang C, Wang H, Wang X. A strategy for ZnO nanorod mediated multi-mode cancer treatment. Biomaterials. 2011 Mar 31;32(7):1906-14.
[10] Hanley C, Layne J, Punnoose A, Reddy KM, Coombs I, Coombs A, Feris K, Wingett D. Preferential killing of cancer cells and activated human T cells using ZnO nanoparticles. Nanotechnology. 2008 Jun 10;19(29):295103.
[11] Ostrovsky S, Kazimirsky G, Gedanken A, Brodie C. Selective cytotoxic effect of ZnO nanoparticles on glioma cells. Nano Research. 2009 Nov 1;2(11):882-90.
[12]Premanathan M, Karthikeyan K, Jeyasubramanian K, Manivannan G. Selective toxicity of ZnO nanoparticles toward Gram-positive bacteria and cancer cells by apoptosis through lipid peroxidation. Nanomedicine: Nanotechnology, Biology and Medicine. 2011 Apr 30;7(2):184-92.
[13] Emima Jeronsia. J, Allwin Joseph, L. and Jerome Das, S. INVESTIGATIONS ON ANTICANCER AND ANTIBACTERIAL ACTIVITIES OF ZINC OXIDE NANOPARTICLES International Journal of Development Research Vol. 5, Issue, 10, pp. 5707-5711, October, 2015[
[14] Wahab R, Siddiqui MA, Saquib Q, Dwivedi S, Ahmad J, Musarrat J, Al-Khedhairy AA, Shin HS. ZnO nanoparticles induced oxidative stress and apoptosis in HepG2 and MCF-7 cancer cells and their antibacterial activity. Colloids and Surfaces B: Biointerfaces. 2014 May 1;117:267-76.
[15] Wahab R, Dwivedi S, Umar A, Singh S, Hwang IH, Shin HS, Musarrat J, Al-Khedhairy AA, Kim YS. ZnO nanoparticles induce oxidative stress in Cloudman S91 melanoma cancer cells. Journal of biomedical nanotechnology. 2013 Mar 1;9(3):441-9.
[16] Hackenberg S, Scherzed A, Kessler M, Froelich K, Ginzkey C, Koehler C, Burghartz M, Hagen R, Kleinsasser N. Zinc oxide nanoparticles induce photocatalytic cell death in human head and neck squamous cell carcinoma cell lines in vitro. International journal of oncology. 2010 Dec 1;37(6):1583-90.
[17] Fang RH, Hu CM, Luk BT, Gao W, Copp JA, Tai Y, O’Connor DE, Zhang L. Cancer cell membrane-coated nanoparticles for anticancer vaccination and drug delivery. Nano letters. 2014 Mar 28;14(4):2181-8.
[18] Bae MY, Cho NH, Seong SY. Protective anti‐tumour immune responses by murine dendritic cells pulsed with recombinant Tat‐carcinoembryonic antigen derived from Escherichia coli. Clinical & Experimental Immunology. 2009 Jul 1;157(1):128-38.
[19] Cho NH, Cheong TC, Min JH, Wu JH, Lee SJ, Kim D, Yang JS, Kim S, Kim YK, Seong SY. A multifunctional core-shell nanoparticle for dendritic cell-based cancer immunotherapy. Nature nanotechnology. 2011 Oct 1;6(10):675-82.
[20] Yun JW, Yoon JH, Kang BC, Cho NH, Seok SH, Min SK, Min JH, Che JH, Kim YK. The toxicity and distribution of iron oxide–zinc oxide core‐shell nanoparticles in C57BL/6 mice after repeated subcutaneous administration. Journal of Applied Toxicology. 2015 Jun 1;35(6):593-602.
[21] Selvakumari D, Deepa R, Mahalakshmi V, Subhashini P, Lakshminarayan N. Anti cancer activity of ZnO nanoparticles on MCF7 (breast cancer cell) and A549 (lung cancer cell). Asian Research Publishing Network Journal of Engineering and Applied Sciences. 2015;10:5418-21.
[22] Bezerra DP, Pessoa C, Moraes MO, Silveira ER, Lima MA, Martins Elmiro FJ, Costa-Lotufo LV. Antiproliferative effects of two amides, piperine and piplartine, from Piper species. Zeitschrift für Naturforschung C. 2005 Aug 1;60(7-8):539-43.
[23] Sriwiriyajan S, Ninpesh T, Sukpondma Y, Nasomyon T, Graidist P. Cytotoxicity screening of plants of genus piper in breast cancer cell lines. Tropical Journal of Pharmaceutical Research. 2014;13(6):921-8.
[24] Roy UB, Vijayalaxmi KK. Evaluation of in vitro antitumor property of ethanolic extract of Piper Nigrum seeds. International Journal of Biotechnology and Allied Fields. 2013;1(9):419-37.
[25] Prashant A, Rangaswamy C, Yadav AK, Reddy V, Sowmya MN, Madhunapantula S. In vitro anticancer activity of ethanolic extracts of Piper nigrum against colorectal carcinoma cell lines. International Journal of Applied and Basic Medical Research. 2017 Jan;7(1):67.