CT-DNA interaction, Fluorescence binding and Microbial activity of Schiff base metal complexes derived from 4-bromobenzaldehyde and 2-amino-6-methylbenzothiazole
DOI:
https://doi.org/10.12723/mjs.64.8Keywords:
2-amino-6-methylbenzothiazole based ligand, metal complexes, CT-DNA binding, Fluorescence, anti microbial studyAbstract
Bidentate ligand (L) was synthesized by knoevenagel reaction using 4-bromobenzaldehyde and 2-amino-6-methylbenzothiazole. The ligand has been confirmed from the analytical technique such as UV-Vis, FTIR, NMR, Mass and EPR spectral. The synthesized metal complexes were characterized from the spectra and physico-chemical techniques. These studies showed that the stoichiometric composition of ML2 type complexes. Absorption study implies that the compounds posses the octahedral geometry and their chelates are electrolytic and monomeric in nature. Absorption and gel electrophoreses experiments set up accepted the effective interaction with CT-DNA molecules. It was extended to Fluorescence emission study of binding. The anti bacterial and anti fungi studies were carried out by disc diffusion method. From the MIC values, metal complexes were controlling larger than Schiff base.
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