Organic Ligand 1-(1-Morpholino-1-(Thiophen-2-yl)Ethyl)-3-Phenylurea: Synthesis, Characterization, Derivatives and Exploration of Bioactivity


  • Dhurairaj Satheesh Loganatha Narayanasamy Government College
  • S. Kannan Research Department of Chemistry, L.N. Government College (Autonomous), Ponneri-601 204, Tamilnadu, India.
  • A. Gomathi PG and Research Department of Chemistry, R.V. Government Arts College, Chengalpattu, Tamilnadu, India.
  • M. Syed Ali Padusha PG and Research Department of Chemistry, Jamal Mohamed College (Autonomous), Trichy, Tamilnadu, India.



Morpholine derivatives, 2-acetylthiophene, Mannich base, metal complexes, DPPH free radical scavenging and anti-inflammatory activities


Organic compounds possessing a comparatively higher number of nitrogens have gained attention in the upcoming fields of medicine and  research. Synthesizing new drugs with a greater number of nitrogen atoms in their structure skeleton places challenges. Unique features, say lipophilicity carried by Mannich bases and their bivalent metal coordination complexes, claim themselves to be potential sources [1-3]. Heterocyclic organic compounds rooted through amines and amides possess enhanced absorption through bio-membranes because of their lipophilicity which results in boundless pharmaceutical applications [4-11]. They considerably shorten the duration of therapy too. Mannich base and its coordination complexes with a range of first transition bivalent metals, such as Co2+, Mn2+, Ni2+, Cu2+, and Zn2+are reported along with DPPH free radical scavenging activity and anti-inflammatory activity. The scheme sequenced with2-acetyl thiophene, morpholine, and phenyl urea was not yet described, the new Mannichbase,1-(1-morpholino-1-(thiophene-2-yl)ethyl)-3-phenyl urea (L), was synthesized.  The compound and all the complexes were characterized.


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