Vol. 24 No. 4 (2025): Mapana Journal of Sciences
Life Sciences

In Vitro Study on Cytotoxic and Apoptotic Property of Chrysopogon zizaniodes Root and Acorus calamus Rhizome Extracts Using UMR-106 Bone Cancer Cell Line

  • Mohan Kumar H. M.
Mohan Kumar H. M.
Nrupathunga University, Bengaluru, Karnataka, India

Published 2025-12-02

Keywords

  • Cytotoxic, Apoptotic, Chrysopogon zizaniodes, Acorus calamus, UMR-106.

Copyright (c) 2025

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Abstract

From the last few years researchers have made lot of efforts to explore anticancer agents from medicinal plants. In the present study, cytotoxic and apoptotic property of Chrysopogon zizaniodes root and Acorus calamus rhizome extracts were evaluated by MTT assay using UMR-106 bone cancer cell lines. The IC50 value of C. zizaniodes and A. calamus were 265.5 µg/ml and 308.7 µg/ml respectively on UMR-106 bone cancer cell line and that of standard doxorubicin was 19.79 µg/ml. As the IC50 value of C. zizaniodes was comparatively less than that of A. calamus, the apoptotic experiment was continued with C. zizaniodes. The treatment of sample C. zizanioides with the concentration of 160 µg/ml and 320 µg/ml was known to induce the apoptosis in UMR-106 cell line.

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