Vol. 23 No. 4 (2024): Upcoming Articles
Research Articles

Identification of active leads in Andrographis Paniculata leaves for controlling the growth of two opportunistic bacteria

  • Vinod P Raphael,
  • Bindu T K,
  • Shaju K S,
  • Sunil Jose T
Vinod P Raphael
Government Engineering College Thrissur
Bindu T K
2Department of Chemistry, Govt. Engineering College, Thrissur, Kerala -680009
Shaju K S
Department of Chemistry, Panampilly Memorial Government College, Thrissur, Kerala-680722
Sunil Jose T
Department of Chemistry, St. Thomas’ College, Thrissur, Kerala-680001

Published 2024-12-23

Keywords

  • Andrographis paniculata,
  • E. faecalis,
  • K. pneumoniae,
  • docking,
  • beta lactamase

Copyright (c) 2024

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Abstract

Opportunistic pathogens like E. faecalis and K. pneumoniae exploit weakened immune systems, causing diverse infections, often resistant to antibiotics. This study explored Andrographis paniculata's potential against these pathogens. Extracts from its leaves, notably acetone, showed significant inhibitory effects on both bacteria. GC-MS analysis identified eighteen compounds; three showed promising drug-like properties. Molecular docking studies revealed Andrographolide's efficacy against essential bacterial enzymes. It inhibited triphosphohydrolase, lactate dehydrogenase, and lipoyl synthase in E. faecalis, and dihydrofolate reductase and SHV-11 beta-lactamase in K. pneumoniae. Andrographolide holds promise for developing novel antibacterial therapeutics. This research underscores the importance of exploring plant-based remedies in combating antibiotic-resistant pathogens, offering potential alternatives for pharmaceutical intervention. Further investigation into the mechanisms of action and in vivo efficacy of Andrographis paniculata extracts and their active compounds is warranted to advance their therapeutic potential in clinical settings.

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