HIV/AIDS Clinical Trials: A Statistical Review

Abstract

The HIV pandemic has grown to become one of the greatest infectious disease threats, to human health and to socio-economic stability that the world has ever encountered.It is imperative that the epidemic is controlled as rapidly as possible through prevention of new infections.Carefully conducted clinical trials are the fastest and safest way to find treatments that work in people to improve health.When the objectives or the endpoints of clinical trials for HIV/AIDS are carefully defined then Statistics will be very useful not only in designing the trial and formulating hypothesis but also in providing guidance in the analysis of the data on completion of the trial and to enhance the credibility of the results.This article mainly reviews the analysis of HIV/AIDS clinical trials.Concepts such as meta-analysis,analysis in the case of incomplete data and Bayesian analysis in the context of HIV/AIDS have also been covered.