Synthesis, Characterization and Biological Activity of Quinoline Bound Imidazoles

Authors

  • Shashiprabha Department of Chemistry, Sri Dharmasthala Manjunatheshwara College (Autonomous), Ujire – 574240.
  • Sanjay S S Department of Chemistry, Sri Dharmasthala Manjunatheshwara College (Autonomous), Ujire – 574240.
  • Vishwanatha P Department of Chemistry, Sri Dharmasthala Manjunatheshwara College (Autonomous), Ujire – 574240.
  • Sudhakar Y N Department of Chemistry, Sri Dharmasthala Manjunatheshwara College (Autonomous), Ujire – 574240.

DOI:

https://doi.org/10.12723/mjs.45.6

Keywords:

Dengue virus, 8-hydroxy quinoline, imidazole, 2-mercaptoimidazole

Abstract

8-Hydroxyqunoline derivatives were synthesised by treating 5-chloromethyl-8-hydroxy quinoline with imidazole and characterized using NMR and mass spectrometry. 2-mercaptoimidazole derivatives of 8-hydroxy quinoline were also synthesized and characterized. One of the compounds in this series has been tested for dengue activity along with other series of compounds, but did not show any activity against dengue virus.

Author Biographies

Shashiprabha, Department of Chemistry, Sri Dharmasthala Manjunatheshwara College (Autonomous), Ujire – 574240.

Department of Chemistry, Sri Dharmasthala Manjunatheshwara College (Autonomous), Ujire – 574240.

Sanjay S S, Department of Chemistry, Sri Dharmasthala Manjunatheshwara College (Autonomous), Ujire – 574240.

Department of Chemistry, Sri Dharmasthala Manjunatheshwara College (Autonomous), Ujire – 574240.

Vishwanatha P, Department of Chemistry, Sri Dharmasthala Manjunatheshwara College (Autonomous), Ujire – 574240.

Department of Chemistry, Sri Dharmasthala Manjunatheshwara College (Autonomous), Ujire – 574240.

Sudhakar Y N, Department of Chemistry, Sri Dharmasthala Manjunatheshwara College (Autonomous), Ujire – 574240.

Department of Chemistry, Sri Dharmasthala Manjunatheshwara College (Autonomous), Ujire – 574240.

References

Solomonides, Tony, Healthgrid applications and core technologies : proceedings of HealthGrid 2010. Amsterdam: IOS Press. p.235.

N. H. Mueller, N. Pattabiraman,; C. Ansarah-Sobrinho, P. Viswanathan, T. C. Pierson, R. Padmanabhan, “Identification and biochemical characterization of small-molecule inhibitors of west nile virus serine protease by a high-throughput screen”, Antimicrob. Agents Chemother. 2008, 52, 3385-3393.

N. H. Mueller, C. Yon, V. K Ganesh, R. Padmanabhan, “Characterization of the West Nile virus protease substrate specificity and inhibitors”, Int. J. Biochem. Cell Biol., vol. 39, 606-614, 2007.

M. Ezgimen, H. Lai, N. H. Mueller, K. Lee, G. Cuny, D. A. Ostrov, Padmanabhan, R. “Characterization of the 8-hydroxyquinoline scaffold for inhibitors of West Nile virus serine protease” Antiviral Res.,94, 18-24, 2012.

J. H. Burckhalter, I. L. Robert, “Amino- and Chloromethylation of 8-Quinolinol. Mechanism of Preponderant ortho Substitution in Phenols under Mannich Conditions”, J.Org. Chem.,vol.26, 4078-4083,1961.

Isidoros, V.; Summit, N. J. U. S. Pat. 1983, 4391808.

C. Yon, T. Teramoto, N. Mueller, J. Phelan, V. K. Ganesh, K. H. Murthy, R. Padmanabhan, “Modulation of the Nucleoside Triphosphatase/RNA Helicase and 5′-RNA Triphosphatase Activities of Dengue Virus Type 2 Nonstructural Protein 3 (NS3) by Interaction with NS5, the RNA-dependent RNA Polymerase”, J. Biol. Chem., vol. 280, 27412-27419, 2005.

Additional Files

Published

2021-08-16

Issue

Vol. 17 No. 2 (2018): Mapana Journal of Sciences

Section

Research Articles

License

Copyright (c) 2018 Shashiprabha, Sanjay S S, Vishwanatha P, Sudhakar Y N

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Most read articles by the same author(s)